When her father loses his job, seven-year-old Ramona Quimby thinks of ways to deal with the many problems that develop.

Caught at an awkward in-between age--too little to stay home alone but too big to enjoy playing with pesty Willa Jean at her sitter's house, Ramona just wants to be her mother's little girl forever.

Ramona meets lots of interesting people in kindergarten class, like Davy whom she keeps trying to kiss and Susan whose springy curls seem to ask to be pulled.

Beezus Quimby tries very hard to be patient with her little sister, but four-year-old Ramona has the habit of doing the most unpredictable, annoying, embarrassing things in the world.

Ramona likes that shes old enough to be counted on, but must everything depend on her? Mrs. Quimby has gone back to work so that Mr. Quimby can return to school, and Ramona is expected to be good for Mrs. Kemp while her parents are away, to be brave enough to ride the school bus by herself, and to put up with being teased by Danny the Yard Ape.

When Ralph and his pesky cousins accidentally make a mess at the Mountain View Inn, Ralph decides that he'd better take his motorcycle and leave. He persuade his young pal Ryan to take him to school, where Ralph is an instant hit with Ryan's classmates. But Ralph doesn't like being told what to do. Worse than that, his precious motorcycle gets broken.

Henry Huggins makes a deal with his father--if Henry can keep his dog Ribsy out of trouble for a month, he can go fishing with his father. Ribsy does his best to make Henry lose the deal.

For the well-meaning Henry Huggins, nothing ever works out quite as planned including getting the bike of his dreams. Luckily his pal Beezus Quimby is there to help! Henry's attempts at raising money for his bike fund keep falling flat. Selling bubble gum on the playground gets him in trouble with his teacher, and then Ribsy's nose for mischief almost ruins Henry s paper route. Even pesky little Ramona Quimby manages to get in the way of Henry's chance...

For Henry Huggins and his friends Robert and Murph, a clubhouse is a place where they can do as they please, without being bothered by girls. The sign that says NO GIRLS ALLOWED -- THIS MEANS YOU especially means Ramona Quimby. Lately Ramona has been following Henry on his newspaper route, embarrassing him in front of Henry's customers. The day Ramona follows Henry to the clubhouse, she wants to teach him girls aren't so bad, but she almost puts an...

Follows the adventures of nine-year-old Ramona at home with big sister Beezus and baby sister Roberta and at school, in fourth grade, in Mrs. Meacham's class.